Discover12 posts
Ideas worth sharing.
Research, reporting, and ideas at the edges of health, biology, and intelligent systems.
Showing 12 of 12 posts
Clinical & healthResidencyRL: Reinforcement Learning in Simulated Clinical EnvironmentspaperarXiv.org4 minResidencyRL is a reinforcement learning method for training clinical AI agents through simulated, multi-turn patient encounters with adversarial LLM simulators and rewards aligned to diagnostic accuracy, management, communication, documentation, and safety. In held-out evaluations, the agent improved diagnostic accuracy under adversarial conditions, reduced missed red flags, and outperformed the base model across reported clinical benchmarks, though real-world validation remains necessary.Read ResidencyRL: Reinforcement Learning in Simulated Clinical Environments (opens in a new tab) 
Clinical & healthSensorFM: Towards a general intelligence and interface for wearable health dataarticleresearch.google10 minGoogle Research presents SensorFM, a foundation model for wearable health data pre-trained on more than one trillion minutes of multimodal sensor data from five million people. The model transfers across 35 health prediction tasks, supports label-efficient adaptation and data infilling, and can help ground a Personal Health Agent in individual physiology.Read SensorFM: Towards a general intelligence and interface for wearable health data (opens in a new tab)Clinical & healthScientists develop AI tool to spot heart failure risk five years before it strikesblogThe Guardian5 minAn Oxford-developed AI tool predicted heart-failure risk five years before onset with 86% accuracy in a study of 72,000 patients in England.Read Scientists develop AI tool to spot heart failure risk five years before it strikes (opens in a new tab) Biology & genomicsGeneral Multimodal Protein Design Enables DNA-Encoding of ChemistryarticlearXiv15 minDISCO co-designs protein sequence and 3D structure around arbitrary biomolecules, producing enzymes that catalyse new-to-nature reactions without pre-specified catalytic residues.Read General Multimodal Protein Design Enables DNA-Encoding of Chemistry (opens in a new tab) Clinical & healthNew sensor sniffs out pneumonia on a patient’s breathblogMIT News5 minMIT engineers developed a breath test that detects disease-related compounds and could diagnose pneumonia and other lung conditions within minutes.Read New sensor sniffs out pneumonia on a patient’s breath (opens in a new tab) Tools & infrastructureLabClaw: A Skill Library for Autonomous Biomedical ResearcharticleLabClaw — Stanford / Princeton4 minAn open-source library of 206 agentic skills spanning biology, clinical medicine, data science, literature search, and autonomous lab workflows.Read LabClaw: A Skill Library for Autonomous Biomedical Research (opens in a new tab) AI & intelligent systemsSycophantic Chatbots Cause Delusional Spiraling, Even in Ideal BayesiansarticlearXiv15 minA modelling and simulation study probing the causal link between chatbot sycophancy and users becoming dangerously confident in false beliefs.Read Sycophantic Chatbots Cause Delusional Spiraling, Even in Ideal Bayesians (opens in a new tab) Biology & genomicsAdvancing regulatory variant effect prediction with AlphaGenomearticleNature15 minAlphaGenome interprets the non-coding regions of human and mouse genomes that regulate gene expression, predicting where genes begin and end, RNA output, and splicing behaviour. Biology & genomicsCRISPR and the Future of Gene Editing in MedicinevideoNature Video22:05A look at how CRISPR-Cas9 and next-generation gene-editing tools are being used in clinical trials for genetic diseases, cancer, and beyond.Read CRISPR and the Future of Gene Editing in Medicine (opens in a new tab) AI & intelligent systemsTowards Expert-Level Medical Question Answering with Large Language ModelspaperGoogle Research35 minMed-PaLM 2 advances medical question answering, reaching expert physician performance on benchmarks including MedQA and PubMedQA.Read Towards Expert-Level Medical Question Answering with Large Language Models (opens in a new tab) 
AI & intelligent systemsLarge language models encode clinical knowledgepaperNature30 minMed-PaLM demonstrated that large language models could approach physician-level performance on medical question-answering benchmarks.Read Large language models encode clinical knowledge (opens in a new tab)
AI & intelligent systemsAI is dreaming up drugs that no one has ever seen. Now we've got to see if they work.articleMIT Technology Review12 minAI automation across drug development could produce faster, cheaper pharmaceuticals—but the real test is whether generated candidates work in humans.Read AI is dreaming up drugs that no one has ever seen. Now we've got to see if they work. (opens in a new tab)